COVID-19 infection and transmission includes complex sequence diversity
Fig 5
(following page). SARS-CoV-2 Transmission Bottleneck Assessment and Infection Sequence Complexity.
a Summary of bottleneck evaluations for 11 donor-recipient pairs. Dates of transmission include June/July 2020 –MT1-RN1, MT2-RN2, NA-MT2, NA-RN2; November 2020/January 2021 – P11-P13, P11-E30, P13-E30; December 3, 2020 –D-P1, D1-P2, D1-P3; January 23, 2021 – D2-P4. Individual results provide the mean predicted number of virions for each transmission event and 95% CI. b-d Transmission graphs showing AAFs between the 11 infected donor and exposed recipient pairs. Infection complexity is demonstrated by an array of AAFs from 0.05 to 1.0 (y-axes). Transmission settings include a VA Clinical Ward b; a VA Emergency Department c; two independent commuter transport vans d. Inset date for each transmission graph show the maximum change in allele frequency (Max AFD), the median allele frequency change (Med AFD), and the average allele frequency change (Avg AFD). Allele sharing assessments were also performed for two randomly chosen pairs who did not work together or have known contact—CLCCB1 & EDCB6: Max: AFD = 99.95%, Med AFD = 0.081%, Avg AFD = 0.221%; SURVCB26 & EDCB5: Max AFD = 100.00%, Med AFD = 0.077%, Avg AFD = 0.249%.