Bracoviruses recruit host integrases for their integration into caterpillar’s genome
Fig 6
Model for C. vestalis bracovirus integration into caterpillar genome.
Schematic diagram of a model for the processes of how the bracovirus DNA circles integrate into host genome via recruitment of viral or host genes. Cotesia vestalis bracovirus (CvBV) are injected into host along with the egg during oviposition. CvBV circles with HIM integrate conservatively into caterpillar genome in two ways. Type a, viral integrase-dependent: Three CvBV-encoded integrases (CvBV INs) CVE05481, CVE05936 and CVE06814 are responsible for the integration of CvBV_06, 15, 17, 20 and 22. Type b, host integrase-dependent: two host integrases (PxIN), PxIN1 and PxIN2 are induced over time and responsible for the integration of CvBV_04, 12 and 21.