mTOR activity is essential for retinal pigment epithelium regeneration in zebrafish
Fig 8
Model of mTOR activity during RPE regeneration.
(A) mTOR activity is rapidly induced in damaged/regenerating RPE cells between 6hpi and 1dpi. (B) Activation of mTOR signaling in RPE cells regulates the expression of immune-related genes, including cytokines and chemokines. (C) mTOR activity is required for the recruitment of macrophages/microglia to the injured/regenerating RPE. (D) mTOR is also activated in macrophages/microglia recruited to the RPE post-injury and these cells are required to maintain mTOR activity in RPE cells during the later stages of the regenerative response. This maintenance occurs in an inflammation-independent manner.