The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation
Fig 6
Expression levels of PFDN3 correlates with survival of ccRCC patients with mutated VHL.
A) Kyte-Doolittle hydrophobicity plot for the whole pVHL213 protein, dashed inset shows the aa144-156 hydrophobic peak, B-D) Analyses by Kaplan-Meier curves to report overall survival of patients with High (grey line) or Low (blue line) PFDN3 expression levels extracted from the TCGA database: B) patients with mutated VHL (mutVHL, n = 197), C) mutVHL patients with an intact aa144-156 region (mutVHL aa144-156+, n = 114), D) mutVHL patients without aa144-156 region (mutVHL aa144-156-, n = 74). P values are indicated below the curves.