Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila
Fig 8
A brain circuitry model of CREB2 and wLTM.
The αβ surface neurons show an evoked calcium response to odors while the γ dorsal neurons show a decreased calcium response to odors in naïve flies. After odor/water association which induces the formation of wLTM, calcium response to training odor was further increased in αβ surface neurons, whereas the calcium response was further decreased in the γ dorsal neurons 24-hour after training. These increased and decreased cellular calcium responses to training odor in αβ surface and γ dorsal neurons, respectively, were abolished by dCREB2b expression, suggesting that training-induced cellular calcium responsive changes in distinct MB subsets form wLTM traces with different neuronal dynamics in thirsty fly.