Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass
Fig 1
In vitro osteoblast mineralized nodule formation is a heritable trait and correlates with in vivo BMD.
(A) Quantification of Alizarin Red-stained cultures of calvarial osteoblasts isolated from 22 inbred mouse strains after 10 days of osteogenic differentiation. Data are presented as mean ± S.E.M. (B) Alizarin Red values correlate significantly with areal BMD in mouse strains (r = 0.54 p = 0.03; BMD data from Ackert1 [35], https://phenome.jax.org/).