Causal relationships between obesity and the leading causes of death in women and men
Fig 2
SNP- and weight selection flowchart with number of SNPs for each obesity trait.
SNPs were selected by combining the primary (“index”) variants associated with the obesity traits P<5×10−9 in a meta-analysis of GIANT and UK Biobank [14,22]. All SNPs were weighted by their sex-specific European estimates for the men- and women-specific analyses, and by the combined-sexes European estimates for the combined-sexes analyses, using estimates from the original genome-wide association study. BMI, body mass index; SNP, single nucleotide polymorphism; WHR, waist-hip-ratio; WHRadjBMI, waist-hip-ratio adjusted for body mass index.