Intestinal NF-κB and STAT signalling is important for uptake and clearance in a Drosophila-Herpetomonas interaction model
Fig 6
JAK-STAT signaling in H.muscarum intake and clearance.
(A) Knocking down of STAT transcription factor in all immunocompetent tissues significantly increased parasite intake and slowed down clearance. (B) In contrast, knocking down STAT in ECs did not influence parasite intake number or clearance time. (C) This was also the case when STAT was knock down in the fat body where only parasite numbers at the earliest time point of 6h were increased. (D) The most significant effect was observed when STAT was silenced in the ISCs, significantly increasing both parasite number intake and clearance time. Two-way ANOVA was used to analyse all data (*p<0.01, **p<0.001, ***p<0.0001).