Argonaute2 and LaminB modulate gene expression by controlling chromatin topology
Fig 6
A model for enhanced transcription upon depletion of LaminB or AGO2.
A) AGO2 associates with genes both outside and inside the LAD/TAD. LaminB scaffolding helps maintain the TAD in a locked structure, likely impairing Pol II recruitment and preventing promoter-enhancer interactions across the TAD border. B) Upon depletion of either AGO2 or LaminB the chromatin topology from the LAD/TAD switches from a locked to a more accessible unlocked structure, thus permitting inter-TAD interactions. As a result, Pol II recruitment and promoter-enhancer interaction may be increased.