Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development
Fig 2
Loss of Ext1 in the lung epithelium abrogates HS synthesis.
(A-H) Immunofluorescent staining for HS (3G10) and HS (10E4) in lungs at E12.5. Ext1 deletion abrogated the 3G10 signaling in the epithelium and basement membrane (A-D), and the 10E4 signaling in the epithelium (E-H). Scale bar: 50μm.