Comparative Genomic Analysis of Drechmeria coniospora Reveals Core and Specific Genetic Requirements for Fungal Endoparasitism of Nematodes
Fig 7
Comparative analysis of the predicted secretome of D. coniospora.
(A) Distribution of sequence-based protein clusters across five nematopathogenic fungal genomes. Only clusters containing at least one secreted protein are shown. Except for empty sectors, in each sector, there are 3 numbers: total number of clusters/number of clusters with members only in nematophagous fungi/number of clusters with at least one member that matches a PHI base entry with an annotation of reduced virulence or loss of pathogenicity. (B) A correspondence analysis of sequence-based clusters of secreted proteins from five nematopathogenic fungi. The first two dimensions are shown. Crosses represent the position of the individual fungal species and circles represent protein clusters. Circles are sized according the number of constituent proteins as indicated. When clusters have identical coordinates, the size of the circle represents the sum of the number of proteins in each cluster. For example, the circle at (2.33, 3.6) corresponds to 19 clusters of proteins, in this case unique to D. coniospora, including Cluster01087. The proximity of each circle to the species’ apices is a measure of the contribution of the species to that cluster’s content. The distance between the circles is a measure of the similarity of their content (number of proteins from each species). (C) Multiple sequence alignment of proteins from the D. coniospora-specific cluster Cluster01087. Only 3 of the 6 proteins are predicted to be secreted (g2506.t1, g2508.t1, g2511.t1; S11 Table).