Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution
Fig 4
(A) A heat map of multiregional methylation profiles of the 8 cases. (B) Differential contribution of different categories of probe to intratumor and intertumor variance. According to intratumor and intertumor variance, Probes were ranked to obtain each indicated number of top-ranked probes. Probes were categorized based on their genomic positions and enrichment of each category in the top-ranked probes was measured. (C) Proportion of indicated types of methylation alterations was calculated for founder (F) and progressor (P) methylation alterations in the 8 cases. P-values were calculated by Wilcoxon signed-rank test on the 8 cases.