Curly Encodes Dual Oxidase, Which Acts with Heme Peroxidase Curly Su to Shape the Adult Drosophila Wing
Fig 4
The heme peroxidase Cysu works with Duox to stabilize the wing.
(A) Knockdown of cysu, but not the other seven Drosophila heme peroxidases, suppresses the Curly wing phenotype. (B) An endogenously tagged mCherry::Cysu is expressed in the late pupal wing. (C) Knockdown of Cysu in the dorsal wing compartment causes downward cupping and bending of the wing resembling Duox knockdown wings. (D) Knockdown of Cysu with apGal4 in a CyK background causes defects in scutellum and notum formation. (E) Cysu::mCherry is expressed in the thorax of control flies, but not those expressing cysu RNAi with apGal4.