Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions
Fig 1
Capacitance, higher-order genetic interactions, and genetic background effects might be related phenomena that involve interactions among capacitating mutations and cryptic variants.
‘YFG’ and ‘yfgΔ’ refer to the wild type and mutant alleles of a gene that can genetically interact with cryptic variants. The green yeast indicates the combination of a capacitating mutation and cryptic variants that shows a phenotypic effect.