The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking
Fig 8
Proposed model for CC2D2A and NINL function in trafficking, docking and fusion of rhodopsin-carrier vesicles.
1) CC2D2A binds NINL and thus provides a docking point at the base of the connecting cilium for incoming vesicles. 2) NINL binds MICAL3 which in turn binds RAB8 that is coating the rhodopsin-carrier vesicles. Since NINL also associates with the cytoplasmic dynein1 motor complex, it provides a link between the carrier vesicles and the motor generating the movement along the microtubules. 3). MICAL3 subsequently interacts with ELKS and its redox activity promotes remodeling of the docking complex resulting in fusion of the vesicle at the periciliary region.