Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation
Fig 2
Beta-cell failure in NZO mice is associated with a modulation of cell adhesion whereas B6-ob/ob mice are protected against diabetes due to an induction of beta-cell cycle.
Overview of results obtained by RNAseq-based transcriptome analysis. Transcriptome of islets from B6-ob/ob and NZO mice that were fed with a carbohydrate-free diet for approximately 15 weeks and subsequently with a carbohydrate-containing diet for 2 days was studied by RNAseq. Indicated are number of genes that are expressed in the islets, those that are differentially expressed (P<0.05, log2 FC > │0.6│) and the quantity of transcripts that are enriched in the indicated pathway as detected by MetaCore.