MMS Exposure Promotes Increased MtDNA Mutagenesis in the Presence of Replication-Defective Disease-Associated DNA Polymerase γ Variants
Figure 3
Q264H and G651S Mip1 variants were not significantly involved in mtDNA replication.
Median frequency (±95% CI) of erythromycin-resistant mutants per 108 rho+ cells of heterozygous diploid strains containing both a wild type MIP1 allele and a mip1 allele with disease-associated mutation with or without exonuclease disrupting mutations in cis in the presence (3 mM) or absence (0 mM) of MMS. Mutant frequencies were determined from at least 20 different independent cultures. CI, confidence interval, MMS, methyl methanesulfonate; mtDNA, mitochondrial DNA.