Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study
Figure 10
Using PheWAS results, Biofilter, and Cytoscape to explore gene-gene connections with KEGG connections.
The LIPC SNP rs1800588 was associated with folate levels, the LPL SNP rs328 was associated with HDL cholesterol, and both of these genes are in the glycerolipid metabolism KEGG pathway in Mexican Americans. The APOA5 SNP rs135506, associated with triglyceride levels in our study, shares the PPAR signaling pathway along with LPL.