A Genome-Wide Assessment of the Role of Untagged Copy Number Variants in Type 1 Diabetes
Figure 4
Quantile-quantile plot comparing the expected versus the observed distribution of the FBAT-CNV P-values.
These plots show the distribution of -2log10(p), which is, under the null, distributed as chi-square with 2 degrees-of-freedom. IgG/TCR loci are discussed elsewhere and not included in these plots. A – N = 3,286 CNVs that passed quality controls and were tested for association. Loci overlapping the MHC region are marked in blue. Loci mapping to, or in strong LD with, the INS VNTR region are marked in red. B – N = 3,214 CNVs passed quality controls and did not overlap or tagged the INS VNTR and the MHC region. C – N = 448 VNTRs targeted by the CGH array that passed quality controls. INS VNTR CNV regions are marked in red as in Figure 3A.