Nebula/DSCR1 Upregulation Delays Neurodegeneration and Protects against APP-Induced Axonal Transport Defects by Restoring Calcineurin and GSK-3β Signaling
Figure 3
Nebula overexpression restores synaptotagmin level and enhances APP delivery to the synaptic terminals.
(A) Representative images of NMJ staining for the indicated genotypes. Scale bars = 10 µm. (B) Levels of SYT and APP in NMJ normalized to flies overexpressing APP;nlat1. n≥5 independent experiments. (C) Larval locomotor activity assay. n = 10 experiments. All values represent mean ± S.E.M, * p≤0.05 compared to control, ** P<0.05 compared to control and APP overexpression.