Introns Regulate Gene Expression in Cryptococcus neoformans in a Pab2p Dependent Pathway
Figure 7
Model for intron-dependent gene expression regulation in C. neoformans.
In a wild type context (CAS3), protein complexes (EJC) are deposited on the mRNA upon splicing and facilitate mRNA export. The presence of these complexes might also protect mRNA from degradation. In the intronless context (cas3Δi), the absence of splicing impedes EJC deposition and the mRNA is inefficiently exported giving more time to Rrp44p and Xrn2p/Pab2p to degrade it.