The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model
Figure 4
Clustering derived from statistically deregulated genes in Ts65Dn, Ms5Yah, and Ts65Dn/Ms5Yah.
Whole genome microarray expression analysis was performed on RNA isolated from whole adult mouse hearts and statistically deregulated genes were assessed using GeneSpring software. Clustering showed proximity between Ts65Dn/Ms5Yah and Ts65Dn arrays on one side, and between wt and Ms5Yah arrays on the other side. Under-expression and over-expression are represented in green and red respectively, expression levels were calculated by comparison to mean expression level of all arrays for each gene.