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Orphan CpG Islands Identify Numerous Conserved Promoters in the Mammalian Genome

Figure 1

Typical CAP-seq profiles for human and mouse tissues.

(A, B) CAP-seq read density profiles (blue) for sperm, blood and cerebellum of human chr17: 43,061,000–43,596,500 (A) and mouse chr1: 136,095,000–136,630,500 (B). Genes (Refseq) are annotated below the CAP-seq profiles with those mapped to the positive and negative strand displayed above and below the chromosome (grey line) respectively. Non-promoter CGIs are denoted by asterisks. See also Figure S1.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1001134.g001