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M-current modulation of cortical slow oscillations: Network dynamics and computational modeling

Fig 2

Modulation of Up and Down states through the blockade of M-current in an illustrative single case.

(A) Raster plots of relative firing rate (MUA) of all Up and Down states detected in control (top row) and blockade of M-current (IM; bottom row). (B) Scatter plot of Up and Down durations. Irregular ellipses stand for the bivariate (2D) kernel density estimated (KDE; see Methods for details).

Fig 2

doi: https://doi.org/10.1371/journal.pcbi.1011246.g002