Systems-level identification of key transcription factors in immune cell specification
Fig 5
Transcriptional waves regulate the development of the mouse immune system.
(A,B) Two transcriptional waves C21 and C29, which are active in all developmental stages. (C,D) Two cell lineage-specific transcriptional waves. C7 is active in DC lineage and C27 is active in stem cells. (E-H) Four examples of stage-specific waves in immune cell development. C15 is active in B.FrE.BM; C38 is active in preT.DN3.Th; C10 is active in T8.Tem.LCMV.d180.Sp; C12 is active in ILC2.SI. Circles in each panel represent specific cells in the developmental stages. Color indicates normalized PageRank scores with red displaying high values (color bar is the same as Fig 4). TF members of the cluster are shown on the bottom right of the panel.