Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1
Fig 7
Interrogation of MLST8 alteration and prognostic value in cancer patients.
(A) Alteration frequency of the MLST8 gene in cancer patients analyzed from TCGA database using cBioPortal (www.cbioportal.org), shown for the most frequently altered tumour types (cut-off > 1%). (B) Frequency of MLST8 alteration in breast cancer patients analyzed using two breast cancer cohorts TCGA and METABRIC. Only patients having MLST8 alterations are displayed for brevity. (C) Breast cancer patients with high MLST8 expression are significantly associated with poorer overall survival outcome compared to those with low MLST8 expression. (D) No significant differences in overall survival between patients having ‘low’ and ‘high’ expression of MAPKAP1, the gene encoding SIN1.