Development of a hybrid model for a partially known intracellular signaling pathway through correction term estimation and neural network modeling
Fig 11
The model prediction accuracy is improved by coupling the available (imperfect) first-principle model with the estimated wc.
Red solid lines and blue empty circles represent simulated and measured TNFα dynamics and IκBα, respectively, in the presence of BFA under three different LPS concentrations. Blue dash lines represent the model predictions without the correction terms (wc).