Development of a hybrid model for a partially known intracellular signaling pathway through correction term estimation and neural network modeling
Fig 9
Generalized prediction capability of the developed hybrid model for the first case study.
The prediction accuracy of the hybrid model is assessed by comparing with true system dynamics when the activity of TNFα equals to (a) 0.7 and (b) 1.7. The dynamics predicted by the original first-principle model (Eq 19) are also plotted for the comparison.