Causal network inference from gene transcriptional time-series response to glucocorticoids
Fig 5
Time-series profiles of experimentally validated causal interactions across gene classes.
For each gene pair, their profiles were from either the original exposure data set or the unperturbed data set. The effects of all covariates beside the causal gene were controlled in the effect gene values to show the conditional Granger-causal relationship. Colors encode gene classes: pink shows immune genes, dark blue/gray shows metabolic genes, teal shows TFs, and brown/tan shows other genes. Darker colors show causal genes and lighter colors show effect genes. The grey line marks zero-centered expression. Each y-axis tick indicates 0.1 unit-variance standardized ln(TPM). See also S7 Table and S2 Fig.