A computational model of induced pluripotent stem-cell derived cardiomyocytes for high throughput risk stratification of KCNQ1 genetic variants
Fig 5
Comparison of ionic currents and response to physiological noise current in T104I and P197S mutant models.
Sample action potentials from simulated cells with differential response to the T104I and P197S mutations are shown with their underlying currents. (A) Example cell #1 shows more AP prolongation in response to the T104I mutation. The underlying behavior of IKr, IKs, and ICaL is shown during the AP, as well as the sum of these three currents (IKr + IKs + ICaL). (B) Example cell #2 shows more AP prolongation in response to the P197S mutation. The underlying behavior of IKr, IKs, and ICaL is shown during the AP, as well as the sum of these three currents (IKr + IKs + ICaL). (C) Example of the physiological noise current applied to the cellular models to track beat-to-beat variability in response to noise. (D) Response of example cell #1 with physiological noise current. (E) Response of example cell #2 with physiological noise current. The application of low amplitude noise current reveals repolarizations abnormalities in the P197S mutation, as indicated with orange stars.