RAVEN 2.0: A versatile toolbox for metabolic network reconstruction and a case study on Streptomyces coelicolor
Fig 2
Schematic illustration of Sco4 model generation by RAVEN 2.0.
Three draft GEMs were automatically reconstructed in de novo based on MetaCyc and KEGG databases. The two GEMs derived from KEGG genome annotation and HMMs were merged and then subsequently combined with the MetaCyc-based model. The reactions and annotations in the combined draft model were used for manual curation of iMK1208 to result in Sco4.