Hybrid stochastic framework predicts efficacy of prophylaxis against HIV: An example with different dolutegravir prophylaxis schemes
Fig 4
Efficacy of different DTG prophylactic regimen.
A: Prophylactic utility of chronically administered oral DTG regimen (homosexual contact [11]). The red-, green and blue dashed boxes mark the considered concentration ranges of DTG [Cmin (pre-dose), Cmax] achieved with 50, 10 and 2mg once daily (OD) oral dosing. The left pointing arrows at the y-axis mark the respective prophylactic efficacy ranges. B: Prophylactic efficacy of chronically adminstered oral DTG regimen with varying adherence levels. The red-, green- and blue lines denote mean prophylactic efficacy for a 50mg, 10mg and 2mg oral DTG regimen. Errorbars depict the 95% confidence bounds for the ensemble estimate, computed using Greenwoods formula. C: Prophylactic efficacy of DTG for ‘PrEP on demand’. Only three doses of oral DTG were ingested at 0, 24 and 48 hours. Homosexual viral exposure occurred within the first dosing interval at either 1, 3, 6, 12, 18 or 23 hours after initiating ‘PrEP on demand’. The red, green and blue lines represent the mean prophylactic efficacy for ‘PrEP on demand’ using 50-, 10 or 2mg respectively, where error bars denote the 95% confidence bounds for the ensemble estimate, computed using Greenwoods formula. D: Prophylactic efficacy for ‘post exposure prophylaxis’ (PEP) with 50mg DTG for various durations of PEP (y-axis; 3, 5, 7 and 9 days) and delayed initiation of PEP after homosexual viral exposure (x-axis; 2, 4, 6, 12 and 24 hours). Error bars mark the 95% confidence bounds computed using Greenwoods formula.