A single Markov-type kinetic model accounting for the macroscopic currents of all human voltage-gated sodium channel isoforms
Fig 1
Electrophysiological protocols commonly used in the considered studies.
A: Series of depolarizations generated from a holding potential, ranging from less to more depolarized values, used for recording current-voltage curves, voltage-peak relationship, conductance-voltage relationship. B: Conditioning (pre-pulse) long depolarizations at different voltages followed by a test depolarization, used for studying the voltage dependence of steady-state inactivation (availability). C: A conditioning long depolarization followed by repolarizations of increasing duration, before the test depolarization, used for studying the recovery from inactivation (repriming).