Protein charge distribution in proteomes and its impact on translation
Fig 3
Average charge of each residue in the first and last 30 amino acids of all recorded proteins from each species.
A. H. sapiens, B. D. melanogaster, C. C. elegans, D. A. thaliana, E. S. cerevisiae proteomes and F. these five proteomes combined. Blue circles represent whole proteomes (H. sapiens 20,177, D. melagnogaster 3,341, C. elegans 3,743, A. thaliana 14,791 and S. cerevisiae 6,721 proteins), whereas red circles represent proteomes minus proteins that possess signal peptides (H. sapiens 16,717 proteins, D. melanogaster 2,883 proteins, C. elegans 3,232 proteins, A. thaliana 12,599 proteins, and S. cerevisiae 6,382 proteins). Our N-terminal analyses show conservation of a neutral residue at position number 1, a negatively charged residue at position number 2 and a concentration of positively charged residues from approximately position number 3 to 10. Our C-terminal analyses show conservation of positively charged residues from approximately amino acids -15 to -10 onwards.