The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt
Fig 2
Network representation for our model of Notch-Wnt interaction.
Our model comprises: (A) the Wnt pathway, (B) the Notch pathway, and (C) crosstalk points. Numbered steps are justified in S1 Text. Major steps involving the β-catenin crosstalk hub are shown in red, while Wnt-dependent steps are shown in purple. Black AND gates signify the formation of intermediate complexes from two molecular partners. Circular end caps indicate inhibition steps.