A Network Model of Local Field Potential Activity in Essential Tremor and the Impact of Deep Brain Stimulation
Fig 6
DBS effects on oscillatory activity.
When the DBS input is applied to the Vim, the effect on the oscillatory activity is both amplitude and frequency dependent. (A) At low amplitudes, DBS changes the frequency of the oscillation, and the relationship between the applied and the resulting frequency is linear. (B) At higher DBS amplitudes, this relationship changes, and the higher the DBS frequency the lower the frequency of the high amplitude oscillation, which is eventually replaced by the low-amplitude, high frequency activity. When the DBS amplitude increases further (C), this switch from low-frequency, high-amplitude activity to low-amplitude, high-frequency activity occurs at a lower stimulation frequency.