Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator
Fig 4
(A) Simulation of gene expression of Rev-erb-α and Bmal1 with other genes (Cry1, Per2 and Dbp) clamped to their constant mean value. Upon doubling the strength of Bmal1 to Rev-erb-α activation, oscillations are rescued with a period of 24h. (B) Simulation of gene expression of Rev-erb-α, Per2 and Cry1, with other genes (Dbp and Bmal1) clamped to their constant mean value. The period lengthens, but oscillations are retained without parameter adjustments being necessary.