A Mathematical Model of Neonatal Rat Atrial Monolayers with Constitutively Active Acetylcholine-Mediated K+ Current
Fig 8
Comparison of model-generated APs with experimental data.
A, AP optical mapping traces obtained from 1 Hz electrical pacing of a NRAM monolayer B, Sequence of APs generated using our monolayer model, also at 1 Hz electrical stimulation. Inset shows steady-state AP generated using our model, overlaid on a representative AP recorded from a NRAM using whole-cell patch-clamp technique. In patch-clamp experiment, the AP was evoked by a single electrical square pulse of strength 100 pA and duration 5 ms, from an artificial resting membrane potential of -85mV, established by means of a holding current.