Cooperative DNA Recognition Modulated by an Interplay between Protein-Protein Interactions and DNA-Mediated Allostery
Fig 3
Correlated motions and allosteric communication pathways.
(A,B) Positional cross-correlation between OCT4 and the DNA in the absence (A) or presence (B) of SOX2. Each docking helix is marked with a star. The two DNA strands are labeled with “+” and “-”. (C,D) Shortest communication paths between K57 from SOX2 and K117 from OCT4 (C) and between M64 from SOX2 and K117 from OCT4 (D). The size of the edges between nodes is proportional to the number of paths crossing them. The shortest path is shown in blue while the suboptimal paths in light brown. See also S4 Fig.