Particle Simulation of Oxidation Induced Band 3 Clustering in Human Erythrocytes
Fig 5
Addition of an irreversible hemichrome attachment scheme prolongs cluster lifetimes.
(A) Schematic representation of a scheme where band 3 only reversibly undergoes transitions into oxidized, phosphorylated, and clustered state (top), and the full scheme of the developed model (bottom) including irreversible formation and attachment of denatured hemoglobin, known as hemichrome, to band 3. (B) Comparison of predicted clustered band 3 levels in using the scheme with only reversible reactions (grey), the developed model (solid black), and experimental results (dotted black, [3]) for control and G6PD deficient RBCs. The graphs for the developed model and experimental results are the same as those of Fig 3, but have been reprinted for comparison.