Perturbation-Expression Analysis Identifies RUNX1 as a Regulator of Human Mammary Stem Cell Differentiation
Fig 1
Schematic of Perturbation-Expression Analysis of Cell States (PEACS).
The PEACS pipeline consists of four steps: (1) perturb a heterogeneous population with a genetic or chemical perturbation, (2) profile gene expression, (3) factor the gene-expression matrix, and (4) analyze the factored gene-expression matrix to identify perturbations that altered cell-state proportions. Shown in the lower right is the SVD formula for matrix factorization.