Chaste: An Open Source C++ Library for Computational Physiology and Biology
Figure 1
3D off-lattice simulation coupled to PDE: 3D simulation of a tumour spheroid.
A cross-section of a tumour spheroid is presented. Cell centres, nodes of a mesh, are represented by spherical shells and coloured according to the local oxygen concentration. Proliferation is dependent on oxygen, which diffuses and is taken up by cells in the spheroid, such that only cells near the outer rim divide. Cell death occurs under low oxygen conditions near the centre of the spheroid. See also Video S1.