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Mutational Analysis of the High-Affinity Zinc Binding Site Validates a Refined Human Dopamine Transporter Homology Model

Figure 5

Model of the EL2.

Structure of the membrane inserted DAT. EL2 is highlighted. The modeled loop is shown in dark red; the disulfide bridge formed by residues C180 and C189 in yellow and the Cα atoms of the glycosylated asparagines in blue. The membrane inserted side chain of W184 is depicted in magenta; the zinc coordinating residues are depicted in green.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1002909.g005