Connecting Macroscopic Observables and Microscopic Assembly Events in Amyloid Formation Using Coarse Grained Simulations
Figure 6
The rigidity of the fibers can be reduced by removing the chirality of the employed model.
In such systems, the fibers can bend to form a ring (depicted as a simulation snapshot in part B), which does not have a loose end available for further growth. This effects the whole growth process (shown in part A as a relative fiber mass concentration depending on time) and it results in a deviation from a global fit to Oosawa's theory, especially at later stages of the fibrillar growth, since there is no such effect included in theory. The fitted values are = 4.0 and
. The black curve represents simulation data and the red curve is the fit.