Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines
Figure 5
Enrichment in insulator-binding protein CTCF at replication U-domains borders.
(A) Mean coverage by CTCF enriched signals versus the distance to the closest U-domain border in K562 cell line for four U-domain size categories: L0.8 Mb, 0.8 Mb
L
1.2 Mb, 1.2 Mb
L
1.8 Mb and 1.8 Mb
L
3 Mb, from light to dark red curves (genome-wide mean value = 0.0051). (B) Same as in (A) but for the GM06990 cell line (blue code shades) (genome-wide mean value = 0.0046).