Why Don't CD8+ T Cells Reduce the Lifespan of SIV-Infected Cells In Vivo?
Figure 1
Effect of ART-treatment on CD8+ T cell function.
A) Frequency of CD107+ CD8 T cells. Cells were stimulated ex vivo with either gag (black), pol (grey) or env (white) peptides and CD107-expression was measured. B) Death rate of short-lived productively infected cells corrected for reduced CTL function after ART treatment at different contribution of CD8+ T cells to total death rate (filled triangles; mean from left to right: 0.67, 0.72, 0.77, 0.83, 0.94, 1.04, 1.16, 1.32, 1.51, 1.67, 2.77d−1) compared to the death rate of short-lived productively infected cells in CD8-depleted animals (open dots; offset to the right, these estimates are independent of f, mean 1.08d−1).