A Novel Approach to Pharmacodynamic Assessment of Antimicrobial Agents: New Insights to Dosing Regimen Design
Figure 4
Time dependent killing; %T>MIC most important.
Kk = 4.0 h−1. C50 = 10.0 mg/l. H = 4.0. Black solid line depicts the relationship between drug concentration and killing rate; black dotted line represents the microbial growth rate. Arrows below represent concentration ranges achieved with various dosing regimens (red – once daily; green – twice daily; blue – four times daily). White area depicts dosing regimens (combinations of daily dose and dosing interval which the average kill rate is >1.0 h−1. Using a daily dose of 6000 mg, the average kill rates for different regimens are: 0.818 h−1 (q24h), 1.303 h−1 (q12h), and 1.950 h−1(q6h).