Patterns of HIV-1 Protein Interaction Identify Perturbed Host-Cellular Subsystems
Figure 8
HIV-1-host interaction patterns, by interaction type.
This network illustrates core patterns of HIV-host interaction. The human host is depicted as a series of cellular subsystems, represented by orange circular nodes, where the diameter of the node is proportional to the number of host proteins within that subsystem. The action that HIV-1 has on these subsystems is depicted by a series of interaction outcomes (blue diamonds). Interactions between HIV-1 and host subsystems are represented by edges where the edge width is proportional to the number of interactions. The directionality of the interaction is implicit in the description of the interaction outcome. For example, the edge linking the MHC protein complex node and the ‘upregulates’ node represents ‘HIV-1 upregulates the MHC protein complex’, whereas the edge linking the cytokine activity node and the ‘activated by’ node represents ‘HIV-1 is activated by cytokine activity’. For clarity, only those interactions that are shared by over half of the host proteins in a subsystem are shown. *Indicates a host subsystem whose subsystem annotation corresponds to a statistically significant group among HDFs ().
Indicates a statistically significant intersection between the subsystem proteins and HDF set (
).