The Mechanism of Ubiquitination in the Cullin-RING E3 Ligase Machinery: Conformational Control of Substrate Orientation
Figure 6
Model of the E2-Rbx1-Cul1-Skp1-Skp2 complex.
E2 (purple, PDB code 1fbv) is docked to Rbx1(gray)-Cul1(blue)-Skp1(red)-Skp2 F-box (yellow) complex (PDB code 1ldk). Skp2 snapshots at 0 ns (orange) and 20 ns (green) for unbound form and 20 ns (cyan) for bound form are superimposed on the crystal structure using the F-box domain as the pivot.