Cooperativity Dominates the Genomic Organization of p53-Response Elements: A Mechanistic View
Figure 3
Structural and energy properties of the four complexes with spacer sizes of 1, 2, 9 and 10 base pairs.
(A) and (B) p53 dimer-dimer interaction energy and p53-DNA interaction energy, respectively. (C) and (D) the distance between the centers mass for the two pairs of p53 core domain for one and ten bp insertion complexes, respectively. The interacting p53 core domain pairs were labeled in Figure 4.